Chlorogenic acid is a phytochemical found in coffee and coffee beans. It has been touted as being able to reduce blood sugar levels and potentially exert an anti-diabetic effect but, it holds promise in many aspects of health and more specifically, as an antibiotics.

A deep down study by a research team led by Dr. Pravindra Kumar, at Department of Biotechnology, IIT Roorkee, unravels the biochemistry and structural mechanism of its antibacterial property.

“Shikimate Pathway”, which is responsible for the synthesis of aromatic amino acids needed for the survival of soil bacteria. Chorismate mutase is an essential enzyme of this pathway and after going through the combining properties of cholorigenic acid; it is shown that it binds to the essential enzyme. Research data says that since the compound binds to the enzyme Chorismate mutase, and blocks the pathway, it can be used to inhibit growth of the bacteria.

As in the laboratory, it has been successfully established the antibacterial properties of chlorogenic acid, and the structural blueprints obtained from this study can help to produce a new class of antibiotics, which can be a potent inhibitor of bacterial growth.

Research team head Dr. Kumar says, the cholorogenic acid target bacteria by inhibiting the enzymes in the “Shikimate Pathway”. Because this metabolic pathway is present only in bacteria – and not in humans or animals – the antibiotic would specifically inhibit the growth of bacteria.


Reference:

Nature Asia Reports

DoB, IIT-R

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